Prof. Castrillon gave an invited talk at the 8th International Workshop on Extreme Scale Programming Models and Middleware, co-located with this year’s International Conference on High Performance Computing, Networking, Storage and Analysis (SC’23) in Denver, USA. In his presentation, Prof. Castrillon talked about domain-specific programming methodologies for domain-specific and emerging computing systems. He presented examples from different projects at the CC Chair, including the EU H2020 EVEREST, the SPP2377, the 6G-life and the SCADS.AI projects, addressing the domains of big-data, physics simulations and machine learning, targeting modern reconfigurable hardware, for emerging memory technologies and for emerging in-memory computing.