cfaed Seminar Series

cfaed Seminar Series

Prof. Arben Merkoçi , ICREA & Catalan Institute of Nanoscience and Nanotechnology (ICN2), Bellaterra (Barcelona), Catalonia, Spain

Nanobiosensors-based diagnostics

16.06.2016 (Thursday) , 13:00 - 14:00
Seminar Room 115 (HAL) , Hallwachsstr. 3 , 01162 Dresden

Development of novel diagnostic tools with interest for point of care applications represents one of the
main research fields for the nanobiotechnology. Efforts are shown to either develop brand new devices
or improve existing ones thanks to the use of nanomaterials and nanotechnologies. Between the
various devices biosensing systems based on electrical or optical transducing schemes are overall in
the focus of interest given the simplicity and cost efficiency of detection. Among the various biosensing
system performance requirements the high sensitivity and selectivity of the response are crucial for
applications in clinical diagnostics. The fulfilment of such requirements means the detection of low
levels of clinical biomarkers in human fluids. Given the fact that biomarkers are present in very low
concentrations the need for biosensing systems that can detect these analytes with high sensitivity and
selectivity that include very low detection limits along with high reproducibility is an important challenge.
To overcome the difficulties in accomplishing all these requirements the main efforts are driven toward
signal amplification and noise reduction of biosensing systems by the incorporation of nanomaterials.
Nanomaterials (NMs) such as carbon nanotubes, graphene, metallic nanoparticles, nanowires and
quantum dots are showing to be excellent materials to be used as electrochemical transducers or
labels in DNA (or genosensors) sensors beside enzymatic sensors, immunosensors, or cell sensors.
The amplification of the detection of biorecognition events (ex. DNA hybridization, immunoreactions
etc) are the most important objectives of the current bioanalytical chemistry. In this context integration
of the catalytic properties of some biomolecules with those of nanomaterials is appearing to be a
promising way to enhance the sensitivity of the bioassays. Examples related to various clinical
biomarkers as well as contaminants detection will be shown. The developed devices and strategies are
intended to be of low cost while offering high analytical performance in screening scenarios beside
other applications. Special emphasis will be given to paper-based platforms, including lateral flow
formats and simple nanopapers with interest for various fields.

Arben Merkoçi is currently ICREA Professor and director of the Nanobioelectronics
& Biosensors Group at Institut Català de Nanociencia i Nanotecnologia (ICN2).
After his PhD (1991) at Tirana University (Albania), in the topic of Ion-Selective-
Electrodes (ISEs) Dr. Merkoçi worked as postdoc and senior researcher/invited
professor in the field of nanobiosensors and lab-on-a-chip technologies in Italy,
Spain, USA and since 2006 at ICN2. Prof. Merkoçi research is focused on the
design and application of cutting edge nanotechnology and nanoscience based
cost/efficient biosensors. The paper/plastic-based nanobiosensors involve
integration of biological molecules (DNA, antibodies, cells and enzymes) and other
(bio)receptors with micro- and nanostructures/motors and applied in diagnostics,
environmental monitoring or safety and security. He has published around 250
peer review research papers, supervised around 25 PhD students and has been
invited to give plenary lectures and keynote speeches in around 100 occasions in
various countries.

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